Research Project Portals

Mission

"Our mission is to build new knowledge about life and its development on a foundation of advanced technologies, standards of highest quality and tradition of exceptional accuracy."

History of the Center

The Theodosius Dobzhansky Center for Genome Bioinformatics was founded in 2011, supported through a grant from Russian Ministry of Sciences and Education. The purpose of this megagrant was to encourage groundbreaking scientific research that would be conducted in Russia’s highest educational and scientific entities under the supervision of the world’s leading scientists.

The foundational goal of the Center is to provide a laboratory where specialists in genetics and bioinformatics, together with students and other researchers, will collaboratively develop, apply and implement innovative computational methods for annotating and describing the genes of different species, to identify their functions and, in the future, deploy those results in meaningful healthcare, agriculture and conservation applications.

At the conclusion of the initial grant period, several important scientific directions had been established and which continue to progress. Currently, Genome Russia is the primary research project, fully supported by Saint Petersburg State University (StPSU). The primary target of the project is collecting, sequencing and analyzing full genomes of various regional populations living in the territory of the Russian Federation. The research compares the genomes with each other and from different ethnos to identify new genetic variations associated with different diseases and the selection of information markers of people migrating into different regions.

Other important projects of the Centre described below.

RESEARCH PROJECTS OF THE CENTER

Genome Russia Project

Genes are the basic “instruction book” for the cells that make up our bodies, and are made out of DNA. The DNA of a person is more than 99% the same as the DNA of any other unrelated person. But no two people have exactly the same DNA except identical twins. Differences in DNA are called genetic variations. They explain some of the physical differences among people, and partly explain why some people get diseases like cancer, diabetes, asthma, and depression, while others do not. Such diseases may also be affected by factors like diet, exercise, smoking, and pollution in the environment, which makes it hard to figure out which genes affect the diseases.

GWATCH - web-based genome browser for genome-wide association studies

GWATCH is a web-based genome browser designed to automate analysis, visualization and release of data from genome-wide association studies (GWAS) and whole genome sequence association studies of genetic epidemiological cohorts. For any association study, GWATCH allows cataloging and viewing of significant statistical results of association tests (p-values, odds ratios, hazard ratios and others) for single or multiple variants (SNP, indels, CNV), for single or multiple tests.

Genome-based Mycobacterium Tuberculosis Variation Database

Comparative genomics of Mycobacterium tuberculosis clinical strains spread in Russia – is one of the research projects conducted at Theodosius Dobzhansky Center for Genome Bioinformatics. We are studying genomic signatures associated with M. tuberculosis clinical and microbiological features. A Database of M. tuberculosis Genome Variations (GMTV) developed by our team, integrates clinical, epidemiological and microbiological information with genome variations based on whole genome sequencing data. This research is conducted in collaboration with St. Petersburg Research institute of Phthisiopulmonology and St. Petersburg Pasteur Institute, and supported by St. Petersburg State University and Russian Foundation for Basic Research (RFBR) grants.

Single-cell analysis of tumor-microenvironment interactions in follicular lymphoma

Follicular lymphoma

Follicular Lymphoma (FL) is a slow-growing cancer of the lymphatic system, which affects one in every three thousand individuals. While existing frontline therapies are effective at suppressing FL, it remains an incurable disease with a median survival of 8-10 years. A fifth of the patients develop resistance to the standard treatment within the first two years. Understanding the mechanisms facilitating resistance and identifying early molecular prognostic indicators remains a high priority.

Assembly, Annotation, and Comparative Analysis of Apomictic Boechera Species Genome

Principal investigator of the project Vladimir Brukhin

Apomixis is asexual way of plant reproduction through seeds, which could be found in more than 400 plant species representing almost 40 families. It is believed that apomixis evolved independently in several taxa from sexual ancestors. Apomixis could be considered as a developmental variation of sexual reproduction in which some steps are lost, reduced, deregulated or desynchronized (Fig.1). The main features of gametophytic apomixis are:

  • Avoidance of meiosis (apomeiosis);
  • Embryo formation via parthenogenesis;
  • Functional endosperm develops either autonomously or pseudogamously (central cell fertilized by sperm cell).

Theodosius Dobzhansky

Geneticist & Evolutionary Biologist
 
Theodosius Dobzhansky American geneticist and evolutionary biologist and a central figure in the field of evolutionary biology is recognized for...

Stephen J O'Brien

Chief Scientific Officer
 
I welcome you to the Site of the brand new Center of Genome Informatics at St Petersburg State University. The...

Vladimir Brukhin

Leading researcher, Deputy Director 
 
Vladimir Brukhin    Leading researcher, Deputy Director  Joined the Theodosius Dobzhansky Center for Genome Bioinformatics in February 2013 right after returning...

Lab's news

SPBU on web site published an article about achievement of the Center and published article.

September, 27 2019 ( Friday at 2pm: Dr. Kirill Vinnikov from Hawaii University (USA) and head of the lab at the Far Eastern Federal University (Vladivostok) "Exome sequencing of non-model species"